Early life and biography

Louis Pasteur was born on December 27, 1822, in Dole in the Jura region of France, into the family of a poor tanner. He grew up in the nearby town of Arbois, where he later had his house and laboratory, these are now a Pasteur museum. He gained degrees in Letters and in Mathematical Sciences before entering the École Normale Supérieure, an elite college. After serving briefly as professor of physics at Dijon Lycée in 1848, he became professor of chemistry at the University of Strasbourg, where he met and courted Marie Laurent, daughter of the university’s rector, in 1849. They were married on May 29, 1849, and together had five children, only two of whom survived to adulthood, two died of typhoid and one of a brain tumor. These personal tragedies inspired Pasteur to try to find cures for diseases such as typhoid.

Work on chirality and the polarization of light

Pasteur separated the left and right crystal shapes from each other to form two piles of crystals: in solution one form rotated light to the left, the other to the right, while an equal mixture of the two forms canceled each other’s effect and does not rotate polarized light.

In Pasteur’s early work as a chemist, he resolved a problem concerning the nature of tartaric acid (1849). A solution of this compound derived from living things (specifically, wine lees) rotated the plane of polarization of light passing through it. The mystery was that tartaric acid derived by chemical synthesis had no such effect, even though its chemical reactions were identical and its elemental composition was the same.

Upon examination of the minuscule crystals of sodium ammonium tartrate, Pasteur noticed that the crystals came in two asymmetric forms that were mirror images of one another. Tediously sorting the crystals by hand gave two forms of the compound: solutions of one form rotated polarized light clockwise, while the other form rotated light counterclockwise. An equal mix of the two had no polarizing effect on light. Pasteur correctly deduced the molecule in question was asymmetric and could exist in two different forms that resemble one another as would left- and right-hand gloves, and that the biological source of the compound provided purely the one type. This was the first time anyone had demonstrated chiral molecules.

Pasteur’s doctoral thesis on crystallography attracted the attention of M. Puillet and he helped Pasteur garner a position of professor of chemistry at the Faculté (College) of Strasbourg.

In 1854, he was named Dean of the new Faculty of Sciences in Lille. In 1856, he was made administrator and director of scientific studies of the École Normale Superieure.

Germ theory

Pasteur demonstrated that fermentation is caused by the growth of microorganisms, and that the emergent growth of bacterium in nutrient broths is not due to spontaneous generation but rather to biogenesis (Omne vivum ex ovo).

Bottle en col de cygne (Swan neck duct) used by Pasteur

He exposed boiled broths to air in vessels that contained a filter to prevent all particles from passing through to the growth medium, and even in vessels with no filter at all, with air being admitted via a long tortuous tube that would not allow dust particles to pass. Nothing grew in the broths unless the flasks were broken open; therefore, the living organisms that grew in such broths came from outside, as spores on dust, rather than spontaneously generated within the broth. This was one of the last and most important experiments disproving the theory of spontaneous generation. The experiment also supported germ theory.

While Pasteur was not the first to propose germ theory (Girolamo Fracastoro, Agostino Bassi, Friedrich Henle and others had suggested it earlier), he developed it and conducted experiments that clearly indicated its correctness and managed to convince most of Europe it was true. Today he is often regarded as the father of germ theory and bacteriology, together with Robert Koch.

Pasteur’s research also showed that the growth of microorganisms was responsible for spoiling beverages, such as beer, wine and milk. With this established, he invented a process in which liquids such as milk were heated to kill most bacteria and molds already present within them. He and Claude Bernard completed the first test on April 20, 1862. This process was soon afterwards known as pasteurization.

Beverage contamination led Pasteur to the idea that microorganisms infecting animals and humans cause disease. He proposed preventing the entry of microorganisms into the human body, leading Joseph Lister to develop antiseptic methods in surgery.

In 1865, two parasitic diseases called pébrine and flacherie were killing great numbers of silkworms at Alais (now Alès). Pasteur worked several years proving it was a microbe attacking silkworm eggs which caused the disease, and that eliminating this microbe within silkworm nurseries would eradicate the disease.

Pasteur also discovered anaerobiosis, whereby some microorganisms can develop and live without air or oxygen, called the Pasteur effect.

Immunology and vaccination

Pasteur’s later work on diseases included work on chicken cholera. During this work, a culture of the responsible bacteria had spoiled and failed to induce the disease in some chickens he was infecting with the disease. Upon reusing these healthy chickens, Pasteur discovered that he could not infect them, even with fresh bacteria; the weakened bacteria had caused the chickens to become immune to the disease, even though they had only caused mild symptoms.

His assistant Charles Chamberland (of French origin) had been instructed to inoculate the chickens after Pasteur went on holiday. Chamberland failed to do this, but instead went on holiday himself. On his return, the month old cultures made the chickens unwell, but instead of the infection being fatal, as it usually was, the chickens recovered completely. Chamberland assumed an error had been made, and wanted to discard the apparently faulty culture when Pasteur stopped him. Pasteur guessed the recovered animals now might be immune to the disease, as were the animals at Eure-et-Loir that had recovered from anthrax.

In the 1870s, he applied this immunization method to anthrax, which affected cattle, and aroused interest in combating other diseases.

Pasteur publicly claimed he had made the anthrax vaccine by exposing the bacillus to oxygen. His laboratory notebooks, now in the Bibliotheque Nationale in Paris, in fact show Pasteur used the method of rival Jean-Joseph-Henri Toussaint, a Toulouse veterinary surgeon, to create the anthrax vaccine. This method used the oxidizing agent potassium dichromate. Pasteur’s oxygen method did eventually produce a vaccine but only after he had been awarded a patent on the production of an anthrax vaccine.

The notion of a weak form of a disease causing immunity to the virulent version was not new; this had been known for a long time for smallpox. Inoculation with smallpox was known to result in far less scarring, and greatly reduced mortality, in comparison with the naturally acquired disease. Edward Jenner had also discovered vaccination, using cowpox to give cross-immunity to smallpox (in 1796), and by Pasteur’s time this had generally replaced the use of actual smallpox material in inoculation. The difference between smallpox vaccination and cholera and anthrax vaccination was that the weakened form of the latter two disease organisms had been generated artificially, and so a naturally weak form of the disease organism did not need to be found.

This discovery revolutionized work in infectious diseases, and Pasteur gave these artificially weakened diseases the generic name of vaccines, to honor Jenner’s discovery. Pasteur produced the first vaccine for rabies by growing the virus in rabbits, and then weakening it by drying the affected nerve tissue.

The rabies vaccine was initially created by Emile Roux, a French doctor and a colleague of Pasteur who had been working with a killed vaccine produced by desiccating the spinal cords of infected rabbits. The vaccine had only been tested on eleven dogs before its first human trial.

This vaccine was first used on 9-year old Joseph Meister, on July 6, 1885, after the boy was badly mauled by a rabid dog. This was done at some personal risk for Pasteur, since he was not a licensed physician and could have faced prosecution for treating the boy. However, left without treatment, the boy faced almost certain death from rabies. After consulting with colleagues, Pasteur decided to go ahead with the treatment. The treatment proved to be a spectacular success, with Meister avoiding the disease; thus, Pasteur was hailed as a hero and the legal matter was not pursued. The treatment’s success laid the foundations for the manufacture of many other vaccines. The first of the Pasteur Institutes was also built on the basis of this achievement.

Legal risk was not the only kind Pasteur undertook. In The Story of San Michele, Axel Munthe writes of the rabies vaccine research:

Pasteur himself was absolutely fearless. Anxious to secure a sample of saliva straight from the jaws of a rabid dog, I once saw him with the glass tube held between his lips draw a few drops of the deadly saliva from the mouth of a rabid bull-dog, held on the table by two assistants, their hands protected by leather gloves.

Because of his study in germs, Pasteur encouraged doctors to sanitize their hands and equipment before surgery. Prior to this, few doctors or their assistants practiced the procedure of washing their hands and equipment.

Louis Pasteur – Chemistry and Microbiology Scientist
source: wikipedia

She has achieved international acclaim for her work in growth factor research, having discovered and characterized, together with Dr Sporn, the cytokine transforming growth factor-β (TGF-β).

Anita B. Roberts (Born: April 3, 1942 ; Died: May 26, 2006) was a molecular biologist who made pioneering observations of a protein, TGF-β, that is critical in healing wounds and bone fractures and that has a dual role in blocking or stimulating cancers. Roberts was the 49th most-cited scientist in the world and the second most-cited female scientist as of 2005.

Roberts was born in Pittsburgh, Pennsylvania, where she grew up. She attended Oberlin College and earned her doctorate in biochemistry from the University of Wisconsin-Madison in 1968. After postdoctoral work at Harvard Medical School, Dr. Roberts joined the National Cancer Institute in 1976. From 1995 to 2004, she served as Chief of the institute’s, and continued her research until her death in 2006.

In the early-1980s, Dr. Roberts and her colleagues at the National Cancer Institute, part of the National Institutes of Health in Bethesda, Maryland began to experiment with the protein, called TGF-β, short for transforming growth factor beta.

Dr. Roberts isolated the protein from bovine kidney tissue and compared her results with TGF-β taken from human blood platelets and placental tissue. Institute researchers then began a series of experiments to determine the protein’s characteristics. They discovered that it helps play a central role in signaling other growth factors in the body to heal wounds and fractures speedily.

TGF-β was later shown to have an effect on regulation of the heartbeat and the response of the eye to aging.

In later research, Dr. Roberts and others found that TGF-β inhibits the growth of some cancers while stimulating growth in advanced cancers, including cancers of the breast and lung.

Dr. Roberts was a former president of the Wound Healing Society. In 2005, she was elected to the American Academy of Arts and Sciences. Roberts herself was diagnosed cancer, stage IV gastric cancer, in March 2004. She received a degree of fame in the cancer community for her blog, detailing her daily struggles with the disease. She died on May 26, 2006, aged 64.

French chemist who, through a conscious revolution, became the father of modern chemistry. As a student, he stated “I am young and avid for glory.” He was educated in a radical tradition, a friend of Condillac and read Maquois’s dictionary. He won a prize on lighting the streets of Paris, and designed a new method for preparing saltpeter. He also married a young, beautiful 13-year-old girl named Marie-Anne, who translated from English for him and illustrated his books. Lavoisier demonstrated with careful measurements that transmutation of water to earth was not possible, but that the sediment observed from boiling water came from the container. He burnt phosphorus and sulfur in air, and proved that the products weighed more than he original. Nevertheless, the weight gained was lost from the air. Thus he established the Law of Conservation of Mass.

Antoine-Laurent de Lavoisier (26 August 1743 - 8 May 1794), the father of modern chemistry, was a French noble prominent in the histories of chemistry and biology. He stated the first version of the law of conservation of mass, recognized and named oxygen (1778) and hydrogen (1783), abolished the phlogiston theory, introduced the metric system, wrote the first extensive list of elements, and helped to reform chemical nomenclature. The concept of the finite nature of matter was first introduced by Antoine Lavoisier during the 18th century. He discovered that, although matter may change its form or shape, its mass always remains the same. Thus, for instance, if water is heated to steam, if salt is dissolved in water or if a piece of wood is burned to ashes, the total mass remains unchanged. The principles of this discovery were elaborated centuries before by Islamic Persia’s great scholar, Abu Rayhan Biruni. Lavoisier was a disciple of the Muslim chemists and physicists and referred to their books frequently. He was also an investor and administrator of the “Ferme Generale” a private tax collection company; chairman of the board of the Discount Bank (later the Banque de France); and a powerful member of a number of other aristocratic administrative councils. All of these political and economic activities enabled him to fund his scientific research. Because of his prominence in the pre-revolutionary government in France, he was beheaded at the height of the French Revolution.

Early life

Born to a wealthy family in Paris, Antoine Laurent Lavoisier inherited a large fortune at the age of five with the passing of his mother. He attended the College Mazarin from 1754 to 1761, studying chemistry, botany, astronomy, and mathematics. His education was filled with the ideals of the French Enlightenment of the time, and he felt fascination for Maquois’s dictionary. From 1761 to 1763, he studied some law at the University of Paris where he received his Bachelor of Law in 1763. At the same time, he continued attending lectures in the natural sciences. Lavoisier’s devotion and passion for chemistry was largely influenced by Étienne Condillac, a prominent French scholar of the 18th century. His first chemical publication appeared in 1764. In collaboration with Jean-Étienne Guettard, Lavoisier worked on a geological survey of Alsace-Lorraine in 1767. At the age of 25, he was elected a member of the French Academy of Sciences, France’s most elite scientific society, for an essay on street lighting and in recognition for his earlier research. In 1769, he worked on the first geological map of France.

Portrait of Monsieur Lavoisier and his Wife, by Jacques-Louis David

In 1771, Lavoisier at age 28, married the 13-year-old Marie-Anne Pierrette Paulze, the daughter of a co-owner of the Ferme. Over time, she proved to be a scientific colleague to her husband. She translated documents from English for him, including Richard Kirwan’s Essay on Phlogiston and Joseph Priestley’s research. She created many sketches and carved engravings of the laboratory instruments used by Lavoisier and his colleagues. She also edited and published Lavoisier’s memoirs (whether any English translations of those memoirs have survived is unknown as of today) and hosted parties at which eminent scientists discussed ideas and problems related to chemistry.

Contributions to chemistry

Research on gases, water, and combustion

Antoine Lavoisier’s famous phlogiston experiment. Engraving by Mme Lavoisier in the 1780s taken from Traite elementaire de chimie (Elementary treatise on chemistry).

The work of Lavoisier was translated in Japan in the 1840s, through the process of Rangaku. Page from Udagawa Yōan’s 1840 Seimi Kaisō.

Lavoisier also demonstrated the role of oxygen in the rusting of metal, as well as oxygen’s role in animal and plant respiration. Working with Pierre-Simon Laplace, Lavoisier conducted experiments that showed that respiration was essentially a slow combustion of organic material using inhaled oxygen. Lavoisier’s explanation of combustion disproved the phlogiston theory, which postulated that materials released a substance called phlogiston when they burned.

Lavoisier also discovered that Henry Cavendish’s ‘inflammable air’, which Lavoisier had termed hydrogen (Greek for “water-former”), combined with oxygen to produce a dew which, as Joseph Priestley had reported, appeared to be water. Lavoisier’s work was partly based on the research of Priestley. However, he tried to take credit for Priestley’s discoveries. This tendency to use the results of others without acknowledgment, then draw conclusions of his own, is said to be characteristic of Lavoisier. In “Sur la combustion en general” (“On Combustion in general,” 1777) and “Considerations Generales sur la Nature des Acides” (“General Considerations on the Nature of Acids,” 1778), he demonstrated that the “air” responsible for combustion was also the source of acidity. In 1779, he named this part of the air “oxygen” (Greek for “becoming sharp” because he claimed that the sharp taste of acids came from oxygen), and the other “azote” (Greek for “no life”). In “Reflexions sur la Phlogistique” (“Reflections on Phlogiston,” 1783), Lavoisier showed the phlogiston theory to be inconsistent.

Pioneer of stoichiometry

Laboratory instruments used by Lavoisier circa 1780s

Lavoisier’s researches included some of the first truly quantitative chemical experiments. He carefully weighed the reactants and products in a chemical reaction, which was a crucial step in the advancement of chemistry. He showed that, although matter can change its state in a chemical reaction, the quantity of matter is the same at the end as at the beginning of every chemical change. These experiments supported the law of conservation of mass, which Lavoisier was the first to state, although Mikhail Lomonosov (1711-1765) had previously expressed similar ideas in 1748 and proved them in experiments. Others who anticipated the work of Lavoisier include Joseph Black (1728-1799), Henry Cavendish (1731-1810), and Jean Rey (1583-1645).

Analytical chemistry and chemical nomenclature

Chemist’s laboratory, from Diderot’s Encyclopedie, with alchemical table of elements

Lavoisier investigated the composition of water and air, which at the time were considered elements. He determined that the components of water were oxygen and hydrogen, and that air was a mixture of gases, primarily nitrogen and oxygen. With the French chemists Claude-Louis Berthollet, Antoine Fourcroy and Guyton de Morveau, Lavoisier devised a systematic chemical nomenclature. He described it in Methode de nomenclature chimique (Method of Chemical Nomenclature, 1787). This system facilitated communication of discoveries between chemists of different backgrounds and is still largely in use today, including names such as sulfuric acid, sulfates, and sulfites.

Lavoisier’s Traite Élementaire de Chimie (Treatise of Elementary Chemistry, 1789, translated into English by Scotsman Robert Kerr) is considered to be the first modern chemistry textbook. It presented a unified view of new theories of chemistry, contained a clear statement of the law of conservation of mass, and denied the existence of phlogiston. This text clarified the concept of an element as a substance that could not be broken down by any known method of chemical analysis, and presented Lavoisier’s theory of the formation of chemical compounds from elements.

While many leading chemists of the time refused to accept Lavoisier’s new ideas, the Traite Élementaire was sufficiently sound to convince the next generation.

Combustion generated by focusing sunlight over flammable materials using lenses, an experiment conducted by Lavoisier in the 1770s

Detail of picture of a combustion experiment

Constant pressure calorimeter , engraving made by madame Lavoisier for thermochemistry experiments.

Legacy

Lavoisier’s fundamental contributions to chemistry were a result of a conscious effort to fit all experiments into the framework of a single theory. He established the consistent use of the chemical balance, used oxygen to overthrow the phlogiston theory, and developed a new system of chemical nomenclature which held that oxygen was an essential constituent of all acids (which later turned out to be erroneous). Lavoisier also did early research in physical chemistry and thermodynamics in joint experiments with Laplace. They used a calorimeter to estimate the heat evolved per unit of carbon dioxide produced, eventually finding the same ratio for a flame and animals, indicating that animals produced energy by a type of combustion reaction.

Lavoisier also contributed to early ideas on composition and chemical changes by stating the radical theory, believing that radicals, which function as a single group in a chemical process, combine with oxygen in reactions. He also introduced the possibility of allotropy in chemical elements when he discovered that diamond is a crystalline form of carbon.

However, much to his professional detriment, Lavoisier actually discovered no new substances, devised no really novel apparatus, and worked out no improved methods of preparation. He was essentially a theorist, and his great merit lay in the capacity of taking over experimental work that others had carried out–without always, unfortunately, adequately recognizing their claims–and by a rigorous logical procedure, reinforced by his own quantitative experiments, of expounding the true explanation of the results. He completed the work of Black, Priestley and Cavendish, and gave a correct explanation of their experiments.

Overall, his contributions are considered the most important in advancing chemistry to the level reached in physics and mathematics during the 18th century.

Lavoisier conducting an experiment on respiration in the 1770s.

Contributions to biology

Lavoisier used a calorimeter to measure heat production as a result of respiration in a guinea pig. The outer shell of the calorimeter was packed with snow, which melted to maintain a constant temperature of 0 °C around an inner shell filled with ice. The guinea pig in the center of the chamber produced heat which melted the ice. The water that flowed out of the calorimeter was collected and weighed. Lavoisier found that 1 kg of melted ice corresponded to 80 kcal of heat production by the guinea pig. Lavoisier concluded, “la respiration est donc une combustion”, that is, respiratory gas exchange is a combustion, like that of a candle burning.^[6]

Law and politics

Lavoisier received a law degree and was admitted to the bar, but never practiced as a lawyer. He did become interested in French politics, and at the age of 26 he obtained a position as a tax collector in the Ferme Generale, a tax farming company, where he attempted to introduce reforms in the French monetary and taxation system to help the peasants. While in government work, he helped develop the metric system to secure uniformity of weights and measures throughout France.

Final days, execution, and aftermath

Statue of Lavoisier, at Hôtel de Ville, Paris.

As one of twenty-eight French tax collectors and a powerful figure in the unpopular Ferme Generale, Lavoisier was branded a traitor during the Reign of Terror by French Revolutionists in 1794. Lavoisier had also intervened on behalf of a number of foreign-born scientists including mathematician Joseph Louis Lagrange, granting them exception to a mandate stripping all foreigners of possessions and freedom. Lavoisier was tried, convicted, and guillotined on 8 May in Paris, at the age of 50.

Lavoisier was actually one of the few liberals in his position. One of his actions that may have sealed his fate was a clash a few years earlier with the young Jean-Paul Marat whom he dismissed curtly after being presented with a preposterous ’scientific invention’. Marat subsequently became a leading revolutionary and one of the French Revolution’s more extreme “professional common men.”

An appeal to spare his life so that he could continue his experiments was cut short by the judge: “The Republic needs neither scientists nor chemists; the course of justice can not be delayed.”

Lavoisier’s importance to science was expressed by Lagrange who lamented the beheading by saying: “Cela leur a pris seulement un instant pour lui couper la tête, mais la France pourrait ne pas en produire un autre pareil en un siècle.” (“It took them only an instant to cut off his head, but France may not produce another like it in a century.”)

One and a half years following his death, Lavoisier was exonerated by the French government. When his private belongings were delivered to his widow, a brief note was included reading “To the widow of Lavoisier, who was falsely convicted.”

About a century after his death, a statue of Lavoisier was erected in Paris. It was later discovered that the sculptor had not actually copied Lavoisier’s head for the statue, but used a spare head of the Marquis de Condorcet, the Secretary of the Academy of Sciences during Lavoisier’s last years. Lack of money prevented alterations being made. The statue was melted down during the Second World War and has not since been replaced. However, one of the main “lycees” (highschools) in Paris and a street in the 8th arrondissement are named after Lavoisier, and statues of him are found on the Hôtel de Ville (photograph, right) and on the façade of the Cour Napoleon of the Louvre.

Biography

Abu al-Qasim was born in the city of El Zahra, six miles northwest of Cordoba, Spain. He was descended from the Ansar Arab tribe who settled earlier in Spain. Few details remain regarding his life, aside from his published work, due to the destruction of El-Zahra during later Spanish-Moorish conflicts. His name first appears in the writings of Abu Muhammad bin Hazm (993 – 1064), who listed him among the greatest physicians of Moorish Spain. But we have the first detailed biography of El-Zahrawi from al-Humaydi’s Jadhwat al-Muqtabis (On Andalusian Savants), completed six decades after El-Zahrawi’s death.

In El-Zahra, he lived most of his life. It is also where he studied, taught and practised medicine and surgery until shortly before his death in about 1013, two years after the sacking of El-Zahra.

Works

Abu al-Qasim was a court physician to the Andalusian caliph Al-Hakam II. He devoted his entire life and genius to the advancement of medicine as a whole and surgery in particular. His best work was the Kitab al-Tasrif. It is a medical encyclopaedia spanning 30 volumes which included sections on surgery, medicine, orthopaedics, ophthalmology, pharmacology, nutrition etc.

In the 14th century, French surgeon Guy de Chauliac quoted al-Tasrif over 200 times. Pietro Argallata (d. 1453) described Abu al-Qasim as “without doubt the chief of all surgeons”. In an earlier work, he is credited to be the first to describe ectopic pregnancy in 963, in those days a fatal affliction. Abu Al-Qasim’s influence continued for at least five centuries, extending into the Renaissance, evidenced by al-Tasrif’s frequent reference by French surgeon Jaques Delechamps (1513-1588).

Page from a 1531 Latin translation by Peter Argellata of El Zahrawi’s treatise on surgical and medical instruments.

Kitab al-Tasrif

Abu al-Qasim’s thirty-chapter medical treatise, Kitab al-Tasrif, published in 1000, covered a broad range of medical topics, including dentistry and childbirth, which contained data that had accumulated during a career that spanned almost 50 years of training, teaching and practice. In it he also wrote of the importance of a positive doctor-patient relationship and wrote affectionately of his students, whom he referred to as “my children”. He also emphasised the importance of treating patients irrespective of their social status. He encouraged the close observation of individual cases in order to make the most accurate diagnosis and the best possible treatment.

Al-Tasrif was later translated into Latin by Gerard of Cremona in the 12th century, and illustrated. For perhaps five centuries during the European Middle Ages, it was the primary source for European medical knowledge, and served as a reference for doctors and surgeons.

Not always properly credited, Abu Al-Qasim’s al-Tasrif described both what would later became known as “Kocher’s method” for treating a dislocated shoulder and “Walcher position” in obstetrics. Al-Tasrif described how to ligature blood vessels before Ambroise Pare, and was the first recorded book to document several dental devices and explain the hereditary nature of haemophilia.

Advances in surgery

Al-Qasim was a surgeon and specialized in curing disease by cauterization. He also invented several devices used during surgery, for the purpose of:

• inspection of the interior of the urethra
• applying and removing foreign bodies from the throat
• inspection of the ear

Al-Qasim also described the use of forceps in vaginal deliveries.

Surgical instruments

In his Al-Tasrif (The Method of Medicine), he introduced his famous collection of over 200 surgical instruments. Many of these instruments were never used before by any previous surgeons. Hamidan, for example, listed at least twenty six innovative surgical instruments that Abulcasis introduced.

Catgut

Abu al-Qasim’s use of catgut for internal stitching is still practised in modern surgery. The catgut appears to be the only natural substance capable of dissolving and is acceptable by the body.

Forceps

In the Al-Tasrif (1000), Abu al-Qasim invented the forceps for extracting a dead fetus, as illustrated in the the Al-Tasrif.^[3]

Ligature

In the Al-Tasrif (1000), Abu al-Qasim introduced the use of ligature for the arteries in lieu of cauterization.

Surgical needle

The surgical needle was invented and described by Abu al-Qasim in his Al-Tasrif (1000).

Other instruments

Other surgical instruments invented by Abu al-Qasim and first described in his Al-Tasrif (1000) include the scalpel, curette, retractor, surgical spoon, sound, surgical hook, surgical rod, and specula.

en.wikipedia.org

He wrote some 450 books on a wide range of subjects, many of which concentrated on philosophy and medicine. His most famous works are The Book of Healing and The Canon of Medicine, which was a standard medical text at many Islamic and European universities up until the 18th century. Ibn Sina developed a medical system that combined his own personal experience with that of Islamic medicine, the medical system of Galen, Aristotelian metaphysics, and ancient Persian, Arabian and Indian medicine. Ibn Sina is regarded as the father of modern medicine, particularly for his introduction of systematic experimentation and quantification into the study of physiology, and for his discovery of the contagious nature of diseases. He is also considered the father of the fundamental concept of momentum in physics.

George Sarton, the father of the history of science, wrote in the Introduction to the History of Science:

“One of the most famous exponents of Muslim universalism and an eminent figure in Islamic learning was Ibn Sina, known in the West as Avicenna (981-1037). For a thousand years he has retained his original renown as one of the greatest thinkers and medical scholars in history. His most important medical works are the Qanun (Canon) and a treatise on Cardiac drugs. The ‘Qanun fi-l-Tibb’ is an immense encyclopedia of medicine. It contains some of the most illuminating thoughts pertaining to distinction of mediastinitis from pleurisy; contagious nature of phthisis; distribution of diseases by water and soil; careful description of skin troubles; of sexual diseases and perversions; of nervous ailments.

Biography

Early life

Ibn Sina’s life is known to us from authoritative sources. A biography, which is widely considered by foremost Arabicists to have been composed by a disciple and later redacted, covers his first thirty years, and the rest are documented by his disciple al-Juzjani, who was also his secretary and his friend.

He was born in Persia around 980 (370 AH) in Afshana, his mother’s home, a small city now part of Uzbekistan. His father, a respected Ismaili scholar, was from Balkh of the Persian province of Khorasan, now part of Afghanistan, and was at the time of his son’s birth the governor of a village in one of the Samanid Nuh ibn Mansur’s estates. He had his son very carefully educated at Bukhara. According to the Encyclopedia of Islam his father and his brother were influenced by Isma’ili propaganda; he was certainly acquainted with its tenets, but refused to adopt them. Ibn Sina’s independent thought was served by an extraordinary intelligence and memory, which allowed him to overtake his teachers at the age of fourteen.

Ibn Sina was put under the charge of a tutor, and his precocity soon made him the marvel of his neighbours; he displayed exceptional intellectual behaviour and was a child prodigy who had memorized the Quran by the age of 7 and a great deal of Persian poetry as well. From a greengrocer he learned arithmetic, and he began to learn more from a wandering scholar who gained a livelihood by curing the sick and teaching the young.

However he was greatly troubled by metaphysical problems and in particular the works of Aristotle. So, for the next year and a half, he also studied philosophy, in which he encountered greater obstacles. In such moments of baffled inquiry, he would leave his books, perform the requisite ablutions, then go to the mosque, and continue in prayer till light broke on his difficulties. Deep into the night he would continue his studies, and even in his dreams problems would pursue him and work out their solution. Forty times, it is said, he read through the Metaphysics of Aristotle, till the words were imprinted on his memory; but their meaning was hopelessly obscure, until one day they found illumination, from the little commentary by Farabi, which he bought at a bookstall for the small sum of three dirhams. So great was his joy at the discovery, thus made by help of a work from which he had expected only mystery, that he hastened to return thanks to God, and bestowed alms upon the poor.

He turned to medicine at 16, and not only learned medical theory, but also by gratuitous attendance on the sick had, according to his own account, discovered new methods of treatment. The teenager achieved full status as a physician at age 18 and found that “Medicine is no hard and thorny science, like mathematics and metaphysics, so I soon made great progress; I became an excellent doctor and began to treat patients, using approved remedies.” The youthful physician’s fame spread quickly, and he treated many patients without asking for payment.

Adulthood

His first appointment was that of physician to the emir, who owed him his recovery from a dangerous illness (997). Ibn Sina’s chief reward for this service was access to the royal library of the Samanids, well-known patrons of scholarship and scholars. When the library was destroyed by fire not long after, the enemies of Ibn Sina accused him of burning it, in order for ever to conceal the sources of his knowledge. Meanwhile, he assisted his father in his financial labours, but still found time to write some of his earliest works.

When Ibn Sina was 22 years old, he lost his father. The Samanid dynasty came to its end in December 1004. Ibn Sina seems to have declined the offers of Mahmud of Ghazni, and proceeded westwards to Urgench in the modern Uzbekistan, where the vizier, regarded as a friend of scholars, gave him a small monthly stipend. The pay was small, however, so Ibn Sina wandered from place to place through the districts of Nishapur and Merv to the borders of Khorasan, seeking an opening for his talents. Shams al-Ma’ali Kavuus, the generous ruler of Dailam and central Persia, himself a poet and a scholar, with whom Ibn Sina had expected to find an asylum, was about that date (1052) starved to death by his troops who had revolted. Ibn Sina himself was at this season stricken down by a severe illness. Finally, at Gorgan, near the Caspian Sea, Ibn Sina met with a friend, who bought a dwelling near his own house in which Ibn Sina lectured on logic and astronomy. Several of Ibn Sina’s treatises were written for this patron; and the commencement of his Canon of Medicine also dates from his stay in Hyrcania.

Ibn Sina subsequently settled at Rai, in the vicinity of modern Tehran, (present day capital of Iran), the home town of Rhazes; where Majd Addaula, a son of the last Buwayhid emir, was nominal ruler under the regency of his mother (Seyyedeh Khatun). About thirty of Ibn Sina’s shorter works are said to have been composed in Rai. Constant feuds which raged between the regent and her second son, Amir Shamsud-Dawala, however, compelled the scholar to quit the place. After a brief sojourn at Qazvin he passed southwards to Hamadãn, where another Deylamite emir had established himself. At first, Ibn Sina entered into the service of a high-born lady; but the emir, hearing of his arrival, called him in as medical attendant, and sent him back with presents to his dwelling. Ibn Sina was even raised to the office of vizier. The emir consented that he should be banished from the country. Ibn Sina, however, remained hidden for forty days in a sheikh’s house, till a fresh attack of illness induced the emir to restore him to his post. Even during this perturbed time, Ibn Sina persevered with his studies and teaching. Every evening, extracts from his great works, the Canon and the Sanatio, were dictated and explained to his pupils. On the death of the emir, Ibn Sina ceased to be vizier and hid himself in the house of an apothecary, where, with intense assiduity, he continued the composition of his works.

Meanwhile, he had written to Abu Ya’far, the prefect of the dynamic city of Isfahan, offering his services. The new emir of Hamadan, hearing of this correspondence and discovering where Ibn Sina was hidden, incarcerated him in a fortress. War meanwhile continued between the rulers of Isfahan and Hamadãn; in 1024 the former captured Hamadan and its towns, expelling the Tajik mercenaries. When the storm had passed, Ibn Sina returned with the emir to Hamadan, and carried on his literary labours. Later, however, accompanied by his brother, a favourite pupil, and two slaves, Ibn Sina escaped out of the city in the dress of a Sufi ascetic. After a perilous journey, they reached Isfahan, receiving an honourable welcome from the prince.

Later life

Avicenna’s tomb in Hamedan, Iran

The remaining ten or twelve years of Ibn Sina’s life were spent in the service of Abu Ja’far ‘Ala Addaula, whom he accompanied as physician and general literary and scientific adviser, even in his numerous campaigns.

During these years he began to study literary matters and philology, instigated, it is asserted, by criticisms on his style. He contrasts with the nobler and more intellectual character of Averroes. A severe colic, which seized him on the march of the army against Hamadãn, was checked by remedies so violent that Ibn Sina could scarcely stand. On a similar occasion the disease returned; with difficulty he reached Hamadãn, where, finding the disease gaining ground, he refused to keep up the regimen imposed, and resigned himself to his fate.

His friends advised him to slow down and take life moderately. He refused, however, stating that: “I prefer a short life with width to a narrow one with length”. On his deathbed remorse seized him; he bestowed his goods on the poor, restored unjust gains, freed his slaves, and every third day till his death listened to the reading of the Qur’an. He died in June 1037, in his fifty-eighth year, and was buried in Hamedan, Iran.

Works

Scarcely any member of the Muslim circle of the sciences, including theology, philology, mathematics, astronomy, physics, and music, was left untouched by the treatises of Ibn Sina. This vast quantity of works – be they full-blown treatises or opuscula – vary so much in style and content (if one were to compare between the ‘ahd made with his disciple Bahmanyar to uphold philosophical integrity with the Provenance and Direction, for example) that Yahya (formerly Jean) Michot has accused him of “neurological bipolarity”.

Ibn Sina wrote at least one treatise on alchemy, but several others have been falsely attributed to him. His book on animals was translated by Michael Scot. His Logic, Metaphysics, Physics, and De Caelo, are treatises giving a synoptic view of Aristotelian doctrine, though the Metaphysics demonstrates a significant departure from the brand of Neoplatonism known as Aristotelianism in Ibn Sina’s world; Arabic philosophers have hinted at the idea that Ibn Sina was attempting to “re-Aristotelianise” Muslim philosophy in its entirety, unlike his predecessors, who accepted the conflation of Platonic, Aristotelian, Neo- and Middle-Platonic works transmitted into the Muslim world.

The Logic and Metaphysics have been printed more than once, the latter, e.g., at Venice in 1493, 1495, and 1546. Some of his shorter essays on medicine, logic, etc., take a poetical form (the poem on logic was published by Schmoelders in 1836). Two encyclopaedic treatises, dealing with philosophy, are often mentioned. The larger, Al-Shifa’ (Sanatio), exists nearly complete in manuscript in the Bodleian Library and elsewhere; part of it on the De Anima appeared at Pavia (1490) as the Liber Sextus Naturalium, and the long account of Ibn Sina’s philosophy given by Muhammad al-Shahrastani seems to be mainly an analysis, and in many places a reproduction, of the Al-Shifa’. A shorter form of the work is known as the An-najat (Liberatio). The Latin editions of part of these works have been modified by the corrections which the monastic editors confess that they applied. There is also a حكمت مشرقيه (hikmat-al-mashriqqiyya, in Latin Philosophia Orientalis), mentioned by Roger Bacon, the majority of which is lost in antiquity, which according to Averroes was pantheistic in tone.

Sciences

Medicine

A Latin copy of the Canon of Medicine, dated 1484, located at the P.I. Nixon Medical Historical Library of The University of Texas Health Science Center at San Antonio.

About 100 treatises were ascribed to Ibn Sina. Some of them are tracts of a few pages, others are works extending through several volumes. The best-known amongst them, and that to which Ibn Sina owed his European reputation, is his 14-volume The Canon of Medicine, which was a standard medical text in Europe and the Islamic world up until the 18th century. The book is known for its introduction of systematic experimentation and quantification into the study of physiology, and for the discovery of contagious diseases. It classifies and describes diseases, and outlines their assumed causes. Hygiene, simple and complex medicines, and functions of parts of the body are also covered. In this, Ibn Sina is credited as being the first to correctly document the anatomy of the human eye, along with descriptions of eye afflictions such as cataracts. It asserts that tuberculosis was contagious, which was later disputed by Europeans, but turned out to be true. It also describes the symptoms and complications of diabetes. Both forms of facial paralysis were described in-depth. In addition, the workings of the heart as a valve are described.

A copy of the Canon of Medicine, dated 1593

An Arabic edition of the Canon appeared at Rome in 1593, and a Hebrew version at Naples in 1491. Of the Latin version there were about thirty editions, founded on the original translation by Gerard de Sablonetta. In the 15th century a commentary on the text of the Canon was composed. Other medical works translated into Latin are the Medicamenta Cordialia, Canticum de Medicina, and the Tractatus de Syrupo Acetoso.

It was mainly accident which determined that from the 12th to the 18th century, Ibn Sina should be the guide of medical study in European universities, and eclipse the names of Rhazes, Ali ibn al-Abbas and Averroes. His work is not essentially different from that of his predecessor Rhazes, because he presented the doctrine of Galen, and through Galen the doctrine of Hippocrates, modified by the system of Aristotle, as well as the Indian doctrines of Sushruta and Charaka.^[12] But the Canon of Ibn Sina is distinguished from the Al-Hawi (Continens) or Summary of Rhazes by its greater method, due perhaps to the logical studies of the former.

The work has been variously appreciated in subsequent ages, some regarding it as a treasury of wisdom, and others, like Averroes, holding it useful only as waste paper. In modern times it has been seen of mainly historic interest as most of its tenets have been disproved or expanded upon by scientific medicine. The vice of the book is excessive classification of bodily faculties, and over-subtlety in the discrimination of diseases. It includes five books; of which the first and second discuss physiology, pathology and hygiene, the third and fourth deal with the methods of treating disease, and the fifth describes the composition and preparation of remedies. This last part contains some personal observations.

He is, like all his countrymen, ample in the enumeration of symptoms, and is said to be inferior to Ali in practical medicine and surgery. He introduced into medical theory the four causes of the Peripatetic system. Of natural history and botany he pretended to no special knowledge. Up to the year 1650, or thereabouts, the Canon was still used as a textbook in the universities of Leuven and Montpellier.

In the museum at Bukhara, there are displays showing many of his writings, surgical instruments from the period and paintings of patients undergoing treatment. Ibn Sina was interested in the effect of the mind on the body, and wrote a great deal on psychology, likely influencing Ibn Tufayl and Ibn Bajjah. He also introduced medical herbs.

Alchemy

In alchemy, Ibn Sina discredited the theory of transmutation of substances believed by some alchemists:

“Those of the chemical craft know well that no change can be effected in the different species of substances, though they can produce the appearance of such change.”

Aromatherapy

Ibn Sina used steam distillation to produce the first essential oils. As a result, he is regarded as a pioneer of aromatherapy.

Astronomy

In 1070, Abu Ubayd al-Juzjani, a pupil of Ibn Sina, claimed that his teacher Ibn Sina had solved the equant problem in Ptolemy’s planetary model.

Chemistry

In chemistry, steam distillation was invented by Ibn Sina in the early 11th century, which he used to produce essential oils.

Earth sciences

Ibn Sina wrote on the earth sciences in The Book of Healing. In geology, he hypothesized two causes of mountains:

“Either they are the effects of upheavals of the crust of the earth, such as might occur during a violent earthquake, or they are the effect of water, which, cutting itself a new route, has denuded the valleys, the strata being of different kinds, some soft, some hard… It would require a long period of time for all such changes to be accomplished, during which the mountains themselves might be somewhat diminished in size.”

Physics

In physics, Ibn Sina was the first to employ an air thermometer in his scientific experiments.

In mechanics, Ibn Sina developed an elaborate theory of motion, in which he made a distinction between the inclination and force of a projectile, and concluded that motion was a result of an inclination (mayl) transferred to the projectile by the thrower, and that projectile motion in a vacuum would not cease. He viewed inclination as a permanent force whose effect is dissipated by external forces such as air resistance. His theory of motion was thus consistent with the concept of inertia in Newton’s first law of motion. Ibn Sina also referred to mayl to as being proportional to weight times velocity, a precursor to the concept of momentum in Newton’s second law of motion. Ibn Sina’s theory of mayl was further developed by Jean Buridan in his theory of impetus.

In optics, Ibn Sina provided a sophisticated explanation for the rainbow phenomenon. Carl Benjamin Boyer described Ibn Sina’s theory on the rainbow as follows:

“Independent observation had demonstrated to him that the bow is not formed in the dark cloud but rather in the very thin mist lying between the cloud and the sun or observer. The cloud, he thought, serves simply as the background of this thin substance, much as a quicksilver lining is placed upon the rear surface of the glass in a mirror. Ibn Sina would change the place not only of the bow, but also of the color formation, holding the iridescence to be merely a subjective sensation in the eye.”

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